Publications
# First author
* Correspondence author
Detailed publications on Google scholar page
2024
Nan Luo#, Qiang Huang#, Liting Dong#, Wenqing Liu, Jinghui Song, Hanxiao Sun, Hao Wu, Yuan Gao, Chengqi Yi*. Near-cognate tRNAs increase the efficiency and precision of pseudouridine-mediated readthrough of premature termination codons. Nat Biotechnol. 2024 Mar 06. ONLINE
Song, J #, Zhuang, Y #, Yi, C.* Programmable RNA base editing via targeted modifications. Nat Chem Biol 2024 Feb 28. ONLINE
Bai, D.#, Zhang, X., Xiang, H., Guo Z., Zhu C.*, Yi C.*. Simultaneous single-cell analysis of 5mC and 5hmC with SIMPLE-seq. Nat Biotechnol. 2024, Feb 09. ONLINE
W Shen#, H Sun#, C Liu#, Y Yi#, Y Hou, Y Xiao, Y Hu, B Lu, J Peng, J Wang, …, Yi C.*. GLORI for absolute quantification of transcriptome-wide m6A at single-base resolution. Nat Protoc 2024 Jan 22. ONLINE
He H#, Wang Y#, Zhang X#, Li X#, Liu C, Yan D, Deng H, Sun W, Yi C*, Wang J*. Age-related noncanonical TRMT6-TRMT61A signaling impairs hematopoietic stem cells. Nat Aging. 2024 Feb;4(2):213-230. ONLINE
2023
Zhang, M.#, Xiao, Y.#, Jiang, Z.#, Yi, C.*. Quantifying m6A and Ψ Modifications in the Transcriptome via Chemical-Assisted Approaches. Acc Chem Res. 2023, Oct 18. ONLINE
[82] Lei Z#, Meng H#, Zhuang Y#, Zhu Q, Yi C.*. Chemical and Biological Approaches to Interrogate off-Target Effects of Genome Editing Tools. ACS Chem. Biol. 2023, Feb 18. ONLINE
[81]Sun, H#, Li, K#, Liu, C#, Yi C.*. Regulation and functions of non-m6A mRNA modifications. Nat Rev Mol Cell Biol 2023 Jun 27. ONLINE
[80] Lei Z#, Meng H#, Rao X, Zhao H, Yi C.*. Detect-seq, a chemical labeling and biotin pull-down approach for the unbiased and genome-wide off-target evaluation of programmable cytosine base editors. Nat Protoc 2023 Jun 5. ONLINE
[79] Rao, Xi#; Zhao, Hua#; Shao, Chu; Yi, C.*. Characterizing off-target effects of genome editors. Current Opinion in Biomedical Engineering 2023 100480. ONLINE
[78] Zhang, M.#, Jiang, Z.#, Ma, Y., Liu, W., Zhuang, Y., Lu, B., Li, K., Peng, J., Yi, C.*. Quantitative profiling of pseudouridylation landscape in the human transcriptome. Nat Chem Biol 2023 Mar 30. ONLINE
2022
[77] Song, J.#, Dong, L.#, Sun, H.#, Luo, N.#, Huang, Q.#, Li, K., Shen, X., Jiang, Z., Lv, Z., Peng, L., Zhang, M., Wang, K., Liu, K., Hong, J., Yi, C.*. CRISPR-free, programmable RNA pseudouridylation to suppress premature termination codons. Mol Cell 2022 Dec 3:S1097-2765(22)01100-5. ONLINE
[76] Chen, L.#, Zhu, B.#, Ru, G.#, Meng, H.#, Yan, Y.#, Hong, M., Zhang, D., Luan, C., Zhang, S., Wu, H., Gao, H., Bai, S., Li, C., Ding, R., Xue, N., Lei, Z., Chen, Y., Guan, Y., Siwko, S., Cheng, Y., Song, G., Wang, L., Yi, C.*, Liu, M.*, Li, D*. Re-engineering the adenine deaminase TadA-8e for efficient and specific CRISPR-based cytosine base editing. Nat Biotechnol 2022 Nov 10. ONLINE
[75] Liu, C.#, Sun, H.#, Yi, Y.#, Shen, W.#, Li, K.#, Xiao, Y., Li, F., Li, Y., Hou, Y., Lu, B., Liu, W., Meng, H., Peng, J., Yi, C.*, Wang, J*. Absolute quantification of single-base m6A methylation in the mammalian transcriptome using GLORI. Nat Biotechnol 2022 Oct 27. ONLINE
[74] Shen, Y.#, Ou, J.#, He, B.#, Yang, J., Liu, H., Wang, L., Wang, B., Gao, L., Yi, C., Peng, J.*, Cen, X.*. 5-Hydroxymethylation alterations in cell-free DNA refect molecular distinctions of difuse large B cell lymphoma at diferent primary sites. Clin Epigenetics 2022 Oct 11;14(1):126. ONLINE
[73] Liu, Y.#, Zhou, J.#, Li, X.#, Zhang, X.#, Shi, J.#, Wang, X., Li, H., Miao, S., Chen, H., He, X., Dong, L., Lee, GR., Zheng, J., Liu, RJ., Su, B., Ye, Y., Flavell, RA.*, Yi, C.*, Wu, Y.*, Li, HB.*. tRNA-m1A modification promotes T cell expansion via efficient MYC protein synthesis. Nat Immunol 2022 Oct;23(10):1433-1444. ONLINE
[72] Liu, Y.#, Li, K.#, Xu, YP.#*, Zhu, Z., Zhao, H., Li, XF., Ye, Q., Yi, C.*, Qin, CF.*. Characterization of m6A modifications in the contemporary Zika virus genome and host cellular transcripts. J Med Virol 2022 Sep;94(9):4309-4318. ONLINE
[71] Xiao, M.#, Lu, B.#, Ding, R., Liu, X., Wu, X., Li, Y., Liu, X., Qiu, L., Zhang, Z., Xie, J., Chen, Y., Zhang, D., Dong, L., Zhang, M., Peng, J., Yang, H., Kudihna, T., Xu, Y., Li, T., Yi, C.*, Zhu, L.*. Metatranscriptomic analysis of host response and vaginal microbiome of patients with severe COVID-19. Sci China Life Sci 2022 Jul;65(7):1473-1476. ONLINE
[70] Zhang, M.#, Sun, H.#, Li, K., Xiao, Y., Yi, C.*. m6Am RNA modification detection by m6Am-seq. Methods 2022 Jul;203:242-248. ONLINE
[69] Zhuo, W.#*, Sun, M.#, Wang, K.#, Zhang, L.#, Li, K., Yi, D., Li, M., Sun, Q., Ma, X., Liu, W., Teng, L., Yi, C.*, Zhou, T.*. m6Am methyltransferase PCIF1 is essential for aggressiveness of gastric cancer cells by inhibiting TM9SF1 mRNA translation. Cell Discov 2022 May 21;8(1):48. ONLINE
[68] Lei, Z.#, Meng, H.#, Liu, L.#, Zhao, H.#, Rao, X., Yan, Y., Wu, H., Liu, M., He, A. & Yi, C.*. Mitochondrial base editor induces substantial nuclear off-target mutations. Nature 2022 606(7915), 804-811. ONLINE
2021
[67] Wang, Y.#*, Wang, J.#, Li, X.#, Xiong, X.#, Wang, J., Zhou, Z., Zhu, X., Gu, Y., Dominissini, D., He, L., Tian, Y.*, Yi, C.* & Fan, Z.* N1-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism. Nature Communications 2021 12(1), 1-19. ONLINE
[66] Zhuang, Y.#, Liu, J.#, Wu, H.#, Zhu, Q., Yan, Y., Meng, H., Chen, P., and Yi, C.* Increasing the efficiency and precision of prime editing with guide RNA pairs. Nat Chem Biol 2021 doi.org/10.1038/s41589-021-0088 PDF ONLINE
[65] Zhang M#, Sun H#, Li K, Xiao Y, Yi C.* m6Am RNA modification detection by m6Am-seq. Methods 2021 Oct 5:S1046-2023(21)00226-7. doi: 10.1016/j.ymeth.2021.10.001. Epub ahead of print. PMID: 34624505. PDF ONLINE
[64] Bai D#, Peng J, Yi C.* Advances in single-cell multi-omics profiling. RSC Chem Biol 2021 Jan 20;2(2):441-449. doi: 10.1039/d0cb00163e. PMID: 34458793; PMCID: PMC8341011. PDF ONLINE
[63] Cui, Q.#, Yin, K.#, Zhang, X.#, Ye, P., Chen, X., Chao, J., Meng, H., Wei, J., Roeth, D., Li, L., Qin, Y., Sun, G.H., Zhang, M.Z., Klein, J., Huynhle, M., Wang, C., Zhang, L.Y., Badie, B., Kalkum, M. He, C., Yi, C.* and Shi, Y.H.* Targeting PUS7 suppresses tRNA pseudouridylation and glioblastoma tumorigenesis. Nature Cancer 2021 PDF ONLINE
[62] Sun, H.#, Li, K.#, Zhang, X., Liu, J.E., Zhang, M., Meng, H. and Yi, C.* m6Am-seq reveals the dynamic m6Am methylation in the human transcriptome. Nature Communications 2021 PDF ONLINE
[61] He, B.#, Zhang, C.#, Zhang, X.#, Fan, Y.#, Zeng, H., Meng, H., Bai, D., Peng, J., Zhang, Q.*, Tao, W*. and Yi, C.* Tissue-specific 5-hydroxymethylcytosine landscape of the human genome. Nature Communications 2021 PDF ONLINE
[60] Liu, M.#, Zhang, J.#, Zhu, C.#, Zhang, X.#, Xiao, W., Yan, Y., Liu, L., Zeng, H., Gao, Y.Q.* and Yi, C.* DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes. Nature Communications 2021 PDF ONLINE
[59] Lei, Z.#, Meng, H.#, Lv, Z.#, Liu, M., Zhao, H., Wu, H., Zhang, X., Liu, L., Zhuang, Y., Yin, K., Yan, Y. And Yi, C.* Detect-seq reveals out-of-protospacer editing and target-strand editing by cytosine base editors. Nature Methods 2021 PDF ONLINE Cover article
[58]Wang, K.#, Peng, J. and Yi, C.* The m6A Consensus Motif Provides a Paradigm of Epitranscriptomic Studies. Biochemistry 2021 PDF ONLINE
[57] Lu, B.#, Yan, Y., Dong, L., Han, L., Liu, Y., Yu, J., Chen, J., Yi, D., Zhang, M., Deng, X. Wang, C., Wang, R., Wang, D. And Yi C* Integrated characterization of SARS-CoV-2 genome, microbiome, antibiotic resistance and host response from single throat swabs. Cell discovery 2021 PDF ONLINE
[56]Liu, J.E.#, Xu, Y.P.#, Li, K.#, Ye, Q.#, Zhou, H.Y.|#, Sun, H., Li, X., Yu, L., Deng, Y.Q., Li, R.T., Cheng, M.L., He, B., Zhou, J., Li, X.F., Wu, A.P. and Yi C* The m6A methylome of SARS-CoV-2 in host cells. Cell research 2021 PDF ONLINE
2020
[55] Lu B#, Dong L#, Yi D#, Zhang M#, Zhu C, Li X, Yi C.* Transposase-assisted tagmentation of RNA/DNA hybrid duplexes. Elife. 2020 Jul 23;9:e54919. doi: 10.7554/eLife.54919. PMID: 32701057; PMCID: PMC7402673. PDF ONLINE
[54] Li X#, Liang QX, Lin JR, Peng J, Yang JH, Yi C*, Yu Y*, Zhang QF*, Zhou KR*. Epitranscriptomic technologies and analyses. Sci China Life Sci. 2020 Apr;63(4):501-515. doi: 10.1007/s11427-019-1658-x. Epub 2020 Mar 11. PMID: 32170629. PDF ONLINE
[53] Zhao, L.Y.#, Song, J., Liu, Y., Song, C.X. and Yi, C.* Mapping the epigenetic modifications of DNA and RNA. Protein & Cell 2020 PDF ONLINE
2019
[52] Liu L#, Zhang Y, Liu M, Wei W, Yi C, Peng J*. Structural Insights into the Specific Recognition of 5-methylcytosine and 5-hydroxymethylcytosine by TAL Effectors. J Mol Biol. 2020 Feb 14;432(4):1035-1047. doi: 10.1016/j.jmb.2019.11.023. Epub 2019 Dec 19. PMID: 31863750. PDF ONLINE
[51] Song, J.#; Zhuang, Y.#; Zhu, C.#; Meng, H.; Lu, B.; Xie, B.; Peng, J; Li, M.*; Yi, C.* Differential roles of human PUS10 in miRNA processing and tRNA pseudouridylation. Nature Chemical Biology 2020 PDF ONLINE
[50] Liu, J.#; Li, K.#; Cai, J.#; Zhang, M.#; Zhang, X.; Xiong, X.; Meng, H.; Xu, X.; Huang, Z.; Peng, J.; Fan, J.*; Yi, C.* Landscape and Regulation of m6A and m6Am Methylome across Human and Mouse Tissues. Molecular cell 2019 PDF ONLINE
[49] Song J#, Yi C.* Reading Chemical Modifications in the Transcriptome. J Mol Biol. 2019 Oct 16:S0022-2836(19)30598-4. doi: 10.1016/j.jmb.2019.10.006. Epub ahead of print. PMID: 31628951. PDF ONLINE
[48]Li X#, Yi C.* A Novel Epigenetic Mark Derived from Vitamin C. Biochemistry. 2020 Jan 14;59(1):8-9. doi: 10.1021/acs.biochem.9b00779. Epub 2019 Sep 20. PMID: 31538774. PDF ONLINE
[47] Zhu C#, Gao Y, Peng J, Tang F, Yi C.* Single-Cell 5fC Sequencing. Methods Mol Biol. 2019;1979:251-267. doi: 10.1007/978-1-4939-9240-9_16. PMID: 31028643. PDF ONLINE
[46] Li X#, Peng J, Yi C.* Acetylation Enhances mRNA Stability and Translation. Biochemistry. 2019 Mar 26;58(12):1553-1554. doi: 10.1021/acs.biochem.9b00061. Epub 2019 Mar 15. PMID: 30875197. PDF ONLINE
[45] Zeng, H.#; He, B.#; Yi, C.* Compilation of modern technologies to map genome-wide cytosine modifications in DNA. ChemBioChem 2019 PDF ONLINE
2018
[44] Sun, H.#; Zhang, M.#; Li, K.; Bai, D.; Yi, C.* Cap-specific, terminal N(6)-methylation by a mammalian m(6)Am methyltransferase. Cell Res. 2019 PDF ONLINE
[43] Zeng, H.#; Mondal, M.#; Song, R. Y.#; Zhang, J.; Xia, B.; Liu, M. H.; Zhu, C. X.; He, B.; Gao, Y. Q.*; Yi, C. Q.* Unnatural Cytosine Bases Recognized as Thymines by DNA Polymerases by the Formation of the Watson-Crick Geometry. Angew Chem Int Edit 2019 PDF ONLINE
[42] Zeng, H.#; He, B.#; Xia, B.; Bai, D. S.; Lu, X. Y.; Cai, J. B.; Chen, L.; Zhou, A. K.; Zhu, C. X.; Meng, H. W.; Gao, Y.; Guo, H. S.; He, C.*; Dai, Q.*; Yi, C. Q.* Bisulfite-Free, Nanoscale Analysis of 5-Hydroxymethylcytosine at Single Base Resolution. J. Am. Chem. Soc. 2018, 140, 13190-13194. PDF ONLINE
[41] Wang, K.#; Yi, C.* Coupling Transcription and Translation via the Epitranscriptomic m(6)A Mark. Biochemistry 2019 PDF ONLINE
[40] Xiong, X.#; Li, X.#; Wang, K.; Yi, C.* Perspectives on topology of the human m(1)A methylome at single nucleotide resolution. RNA 2018, 24, 1437-1442. PDF ONLINE
[39] Xiong, X.#; Li, X.#; Yi, C.* N(1)-methyladenosine methylome in messenger RNA and non-coding RNA. Curr. Opin. Chem. Biol. 2018, 45, 179-186. PDF ONLINE
[38] Shu, X.#; Liu, M.#; Lu, Z.#; Zhu, C.; Meng, H.; Huang, S.; Zhang, X.; Yi, C.* Genome-wide mapping reveals that deoxyuridine is enriched in the human centromeric DNA. Nat. Chem. Biol. 2018, 14, 680-687. PDF ONLINE
[37] Zeng, H.#; He, B.#; Yi, C.*; Peng, J.* Liquid biopsies: DNA methylation analyses in circulating cell-free DNA. J Genet Genomics 2018, 45, 185-192. PDF ONLINE
2017
[36] Zhu, R.#; Song, Y.#; Liu, H.#; Yang, Y.; Wang, S.; Yi, C.; Chen, P. R.* Allosteric histidine switch for regulation of intracellular zinc(II) fluctuation. Proc Natl Acad Sci U S A 2017, 114, 13661-13666. PDF ONLINE
[35] Li, X.#; Xiong, X.#; Zhang, M.#; Wang, K.#; Chen, Y.#; Zhou, J.; Mao, Y.; Lv, J.; Yi, D.; Chen, X. W.; Wang, C.; Qian, S. B.; Yi, C.* Base-Resolution Mapping Reveals Distinct m(1)A Methylome in Nuclear- and Mitochondrial-Encoded Transcripts. Mol. Cell 2017, 68, 1-13. PDF ONLINE
[34] Zhang, Y.#; Liu, L.#; Guo, S.#; Song, J.#; Zhu, C.; Yue, Z.; Wei, W.*; Yi, C.* Deciphering TAL effectors for 5-methylcytosine and 5-hydroxymethylcytosine recognition. Nat Commun 2017, 8, 901. PDF ONLINE
[33] Lei, Z.#; Yi, C.* A Radiolabeling-Free, qPCR-Based Method for Locus-Specific Pseudouridine Detection. Angewandte Chemie 2017, 56, 14878-14882. PDF ONLINE
[32] Zhu, C.#; Gao, Y.#; Guo, H.#; Xia, B.#; Song, J.; Wu, X.; Zeng, H.; Kee, K.; Tang, F.*; Yi, C.* Single-Cell 5-Formylcytosine Landscapes of Mammalian Early Embryos and ESCs at Single-Base Resolution. Cell Stem Cell 2017, 20, 1-12. PDF ONLINE
[31] Xiong, X.; Yi, C.; Peng, J.* Epitranscriptomics: Toward A Better Understanding of RNA Modifications. Genomics Proteomics Bioinformatics 2017, 15, 147-153. PDF ONLINE
[30] Li, X.#; Peng, J.#; Yi, C.* Transcriptome-Wide Mapping of N1-Methyladenosine Methylome. Methods Mol Biol 2017, 1562, 245-255. PDF ONLINE
[29] Song, J#.; Yi, C.* Chemical Modifications to RNA: A New Layer of Gene Expression Regulation. ACS Chem Biol 2017, 12, 316-325. PDF ONLINE
2016
[28] Zhu, C.#; Lu, L.#; Zhang, J.#; Yue, Z.; Song, J.; Zong, S.; Liu, M.; Stovicek, O.; Gao, Y. Q.; Yi, C.* Tautomerization-dependent recognition and excision of oxidation damage in base-excision DNA repair. Proc Natl Acad Sci U S A 2016, 113, 7792-7797. PDF ONLINE
[27] Shu, X.#; Xiong, X.#; Song, J.; He, C.*; Yi, C.* Base-Resolution Analysis of Cisplatin-DNA Adducts at the Genome Scale. Angew. Chem. Int. Ed. Engl. 2016, 55, 14246-14249. PDF ONLINE
[26] Peng, J.#; Xia, B.; Yi, C.* Single-base resolution analysis of DNA epigenome via high-throughput sequencing. Sci China Life Sci 2016, 59, 219-226. PDF ONLINE
[25] Li, X.#; Xiong, X.; Yi, C.* Epitranscriptome sequencing technologies: decoding RNA modifications. Nat Methods 2016, 14, 23-31. PDF ONLINE
[24] Li, X.#; Xiong, X.#; Wang, K.; Wang, L.; Shu, X.; Ma, S.; Yi, C.* Transcriptome-wide mapping reveals reversible and dynamic N(1)-methyladenosine methylome. Nat. Chem. Biol. 2016, 12, 311-316. PDF ONLINE
[23] Li, X.#; Ma, S.#; Yi, C.* Pseudouridine: the fifth RNA nucleotide with renewed interests. Curr. Opin. Chem. Biol. 2016, 33, 108-116. PDF ONLINE
2015
[22] Xia, B.#; Han, D.#; Lu, X.#; Sun, Z.; Zhou, A.; Yin, Q.; Zeng, H.; Liu, M.; Jiang, X.; Xie, W.; He, C.*; Yi, C.* Bisulfite-free, base-resolution analysis of 5-formylcytosine at the genome scale. Nat. Methods 2015, 12, 1047-1050. PDF ONLINE
[21] Song, J.#; Zhu, C.; Zhang, X.; Wen, X.; Liu, L.; Peng, J.; Guo, H.; Yi, C.* Biochemical and Structural Insights into the Mechanism of DNA Recognition by Arabidopsis ETHYLENE INSENSITIVE3. Plos One 2015, 10, e0137439. PDF ONLINE
[20] Li, X.#; Zhu, P.#; Ma, S.#; Song, J.; Bai, J.; Sun, F.; Yi, C.* Chemical pulldown reveals dynamic pseudouridylation of the mammalian transcriptome. Nat. Chem. Biol. 2015, 11, 592-597. PDF ONLINE
[19] Karijolich, J.; Yi, C.; Yu, Y. T. Transcriptome-wide dynamics of RNA pseudouridylation. Nat. Rev. Mol. Cell Biol. 2015, 16, 581-585. PDF ONLINE
2014
[18] Zhu, C.#; Yi, C.* Switching demethylation activities between AlkB family RNA/DNA demethylases through exchange of active-site residues. Angew. Chem. Int. Ed. Engl. 2014, 53, 3659-3662. PDF ONLINE
[17] Zhang, X.#; Zhu, Z.#; An, F.; Hao, D.; Li, P.; Song, J.; Yi, C.*; Guo, H.* Jasmonate-activated MYC2 represses ETHYLENE INSENSITIVE3 activity to antagonize ethylene-promoted apical hook formation in Arabidopsis. Plant Cell 2014, 26, 1105-1117. PDF ONLINE
[16] Yin, Y.#; Yang, L.#; Zheng, G.; Gu, C.; Yi, C.; He, C.; Gao, Y. Q.; Zhao, X. S.* Dynamics of spontaneous flipping of a mismatched base in DNA duplex. Proc Natl Acad Sci U S A 2014, 111, 8043-8048. PDF ONLINE
[15] Lu, L.#; Zhu, C.; Xia, B.; Yi, C.* Oxidative demethylation of DNA and RNA mediated by non-heme iron-dependent dioxygenases. Chem Asian J 2014, 9, 2018-2029. PDF ONLINE
[14] Li, X.#; Song, J.#; Yi, C.* Genome-wide mapping of cellular protein-RNA interactions enabled by chemical crosslinking. Genomics Proteomics Bioinformatics 2014, 12, 72-78. PDF ONLINE
2013
[13] **Yi, C.**#; He, C.* DNA repair by reversal of DNA damage. Cold Spring Harb Perspect Biol 2013, 5, a012575. PDF ONLINE
2012
[12] **Yi, C.**#; Chen, B.; Qi, B.; Zhang, W.; Jia, G.; Zhang, L.; Li, C. J.; Dinner, A. R.; Yang, C. G.; He, C.* Duplex interrogation by a direct DNA repair protein in search of base damage. Nat. Struct. Mol. Biol. 2012, 19, 671-676. PDF ONLINE
[11] Song, C. X.#; Yi, C.; He, C.* Mapping recently identified nucleotide variants in the genome and transcriptome. Nat. Biotechnol. 2012, 30, 1107-1116. PDF ONLINE
[10] Parisien, M.#; **Yi, C.**#; Pan, T.* Rationalization and prediction of selective decoding of pseudouridine-modified nonsense and sense codons. RNA 2012, 18, 355-367. PDF ONLINE
2011
[9] **Yi, C.**#; Pan, T.* Cellular dynamics of RNA modification. Acc. Chem. Res. 2011, 44, 1380-1388. PDF ONLINE
[8] Song, C. X.#; Szulwach, K. E.; Fu, Y.; Dai, Q.; Yi, C.; Li, X.; Li, Y.; Chen, C. H.; Zhang, W.; Jian, X.; Wang, J.; Zhang, L.; Looney, T. J.; Zhang, B.; Godley, L. A.; Hicks, L. M.; Lahn, B. T.; Jin, P.; He, C.* Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine. Nat. Biotechnol. 2011, 29, 68-72. PDF ONLINE
[7] Jia, G.#; Fu, Y.#; Zhao, X.#; Dai, Q.; Zheng, G.; Yang, Y.; Yi, C.; Lindahl, T.; Pan, T.; Yang, Y. G.; He, C.* N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat. Chem. Biol. 2011, 7, 885-887. PDF ONLINE
2010
[6] **Yi, C.**#; Jia, G.; Hou, G.; Dai, Q.; Zhang, W.; Zheng, G.; Jian, X.; Yang, C. G.; Cui, Q.; He, C.* Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase. Nature 2010, 468, 330-333. PDF ONLINE
[5] Lu, L.#; Yi, C.; Jian, X.; Zheng, G.; He, C.* Structure determination of DNA methylation lesions N1-meA and N3-meC in duplex DNA using a cross-linked protein-DNA system. Nucleic Acids Res. 2010, 38, 4415-4425. PDF ONLINE
[4] Chen, H.#; Yi, C.; Zhang, J.; Zhang, W.; Ge, Z.; Yang, C. G.; He, C.* Structural insight into the oxidation-sensing mechanism of the antibiotic resistance of regulator MexR. EMBO Rep 2010, 11, 685-690. PDF ONLINE
2009
[3] **Yi, C.**#; Yang, C. G.; He, C.* A non-heme iron-mediated chemical demethylation in DNA and RNA. Acc. Chem. Res. 2009, 42, 519-529. PDF ONLINE
2008
[2] Yang, C. G.#; **Yi, C.**#; Duguid, E. M.; Sullivan, C. T.; Jian, X.; Rice, P. A.; He, C.* Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA. Nature 2008, 452, 961-965. PDF ONLINE
[1] Jia, G.#; Yang, C. G.#; Yang, S.; Jian, X.; Yi, C.; Zhou, Z.; He, C.* Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO. FEBS Lett. 2008, 582, 3313-3319. PDF ONLINE